Prostaglandin-endoperoxide synthase 2
Ilme
human enzyme involved in inflammation
osa objektist
Prostaglandin G/H synthase 2[7]
Haem peroxidase domain superfamily, animal type[7]
Haem peroxidase superfamily[7]
EGF-like domain, protein family[8]
found in taxon
Homo sapiens[6]
encoded by
PTGS2[6]
molecular function
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[9][19]
määramismeetod: IEA, TAS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[13]
määramismeetod: IEA
cell component
biological process
positive regulation of cell migration involved in sprouting angiogenesis[34][13]
määramismeetod: ISS, IEA
positive regulation of vascular endothelial growth factor production[34][13]
määramismeetod: ISS, IEA
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[13]
määramismeetod: IEA
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[13]
määramismeetod: IEA
physically interacts with
EC enzyme number
1.14.99.1
täpne vaste
koosseisu osa
EGF-like domain[7]
Commonsi kategooria
Cyclooxygenase 2
Viited
- ↑ Freebase Data Dumps, 28. oktoober 2013
- ↑ NCBI Gene, 30. mai 2020, 5743
- ↑ 3,0 3,1 3,2 3,3 3,4 3,5 P35354, 9. august 2016, UniProt, inglise keel
- ↑ Ensembl Release 99, ENSP00000356438
- ↑ Ensembl Release 99, ENSP00000454130
- ↑ 6,0 6,1 6,2 6,3 UniProt, 13. november 2019, P35354
- ↑ 7,0 7,1 7,2 7,3 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
- ↑ inferred from protein domain or family
- ↑ 9,0 9,1 9,2 9,3 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, Reactome, GOA
- ↑ 10,00 10,01 10,02 10,03 10,04 10,05 10,06 10,07 10,08 10,09 10,10 10,11 10,12 10,13 10,14 10,15 IEA, 9. mai 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ 11,0 11,1 11,2 11,3 11,4 ISS, 9. mai 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ 12,0 12,1 12,2 12,3 12,4 12,5 12,6 12,7 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, InterPro, GOA
- ↑ 13,00 13,01 13,02 13,03 13,04 13,05 13,06 13,07 13,08 13,09 13,10 13,11 13,12 13,13 13,14 13,15 13,16 13,17 13,18 13,19 13,20 13,21 13,22 13,23 13,24 13,25 13,26 13,27 13,28 13,29 13,30 13,31 13,32 13,33 13,34 13,35 13,36 13,37 13,38 13,39 13,40 13,41 13,42 13,43 13,44 13,45 13,46 13,47 13,48 13,49 13,50 13,51 13,52 13,53 13,54 13,55 13,56 13,57 13,58 13,59 13,60 13,61 13,62 13,63 13,64 13,65 13,66 13,67 13,68 13,69 13,70 13,71 13,72 13,73 13,74 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Ensembl genome database project, GOA
- ↑ IPI, 9. mai 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ NAS, 7. november 2018, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ 17,0 17,1 IEA, 7. november 2018, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ 18,0 18,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, InterPro, GOA
- ↑ 19,0 19,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, Ensembl genome database project, GOA
- ↑ IDA, 7. november 2018, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7. november 2018, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
- ↑ 22,0 22,1 NAS, 9. mai 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ IDA, 9. mai 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ 24,0 24,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
- ↑ IDA, 9. mai 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Mouse Genome Informatics, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Human Protein Atlas, GOA
- ↑ 30,0 30,1 30,2 30,3 30,4 30,5 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Reactome, GOA
- ↑ IEP, 9. mai 2019, P35354, Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ 32,0 32,1 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, GOA
- ↑ 33,0 33,1 NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
- ↑ 34,0 34,1 34,2 34,3 34,4 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA
- ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
- ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9. mai 2019, Gene Ontology Consortium, GOA
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4139, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7124, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7141, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2892, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2714, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7185, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2896, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4194, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2713, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4795, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 6661, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2897, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7219, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2593, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7220, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5230, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7401, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 8976, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7252, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5239, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7270, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7273, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 8741, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2893, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7298, inglise keel
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2894, inglise keel
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL154
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1034
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL2107455
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1071
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1835207
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL25
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL521
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL166863
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL469
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL53292
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL139
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL622
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1077
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1297
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL898
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL435298
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1200804
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL2103736
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1201124
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1200806
- ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL1200613
- ↑ Identifiers.org