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solute carrier family 6 member 4

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mammalian protein found in Homo sapiens

Välised allikad

Microsoft Academic ID
2778897192
2909985787
RefSeq protein ID
NP_001036[1]
Transporter Classification Database ID
2.A.22.1.1[2][3]
Ensembl protein ID
ENSP00000261707[4]
ENSP00000385822[5]
ENSP00000378298[6]
ENSP00000463172[7]
ENSP00000498537[8]
UniProt protein ID
P31645[9]
Freebase
/m/02fm_d[10]
PDB structure ID
5I6X[11]
5I73[11]
5I75[11]
5I6Z[11]
5I71[11]
5I74[11]
OpenAlex ID
C2778897192[12]

üksikjuht nähtusest

valk[9]

osa objektist

Sodium:neurotransmitter symporter[13][14]
Sodium:neurotransmitter symporter superfamily[13]
Sodium:neurotransmitter symporter, serotonin, N-terminal domain, protein family[15]

found in taxon

Homo sapiens[9]

encoded by

SLC6A4[9]

molecular function

cocaine binding[16]

määramismeetod: IEA

nitric-oxide synthase binding[16]

määramismeetod: IEA

protein homodimerization activity[16]

määramismeetod: IEA

myosin binding[16]

määramismeetod: IEA

syntaxin-1 binding[16]

määramismeetod: IEA

metal ion binding[17]

määramismeetod: IEA

neurotransmitter:sodium symporter activity[18]

määramismeetod: IEA

actin filament binding[19][16]

määramismeetod: ISS, IEA

monoamine transmembrane transporter activity[20]

määramismeetod: IDA

ravimi seotus vereplasma valkudega[21][22][23][24]

määramismeetod: IPI

symporter activity[17]

määramismeetod: IEA

serotonin:sodium symporter activity[25][26][27][28][29]

määramismeetod: IDA, IEA, IMP, TAS

dopamine:sodium symporter activity[30]

määramismeetod: IBA

serotonin:sodium symporter activity[31][32][33][34][35][36]

määramismeetod: IBA, IDA, IEA, IMP, TAS

serotonin binding[37]

määramismeetod: IBA

serotonin:sodium symporter activity[38][18][16][39][37]

määramismeetod: IBA, IDA, IEA, TAS

cell component

integral component of membrane[17][18]

määramismeetod: IEA

tsütosool[40]

määramismeetod: IDA

endosome[17]

määramismeetod: IEA

membrane[17]

määramismeetod: IEA

integral component of plasma membrane[27][41][30]

määramismeetod: IBA, IC, IEA

membrane raft[16][42]

määramismeetod: IDA, IEA

neuron projection[16][37]

määramismeetod: IBA, IEA

endosome membrane[17]

määramismeetod: IEA

endomembrane system[17][16][43][44]

määramismeetod: IDA, IEA

presynapse[45]

määramismeetod: IEA

Rakumembraan[25][46][28][47][48][49][50]

määramismeetod: IDA, IEA, TAS

integral component of postsynaptic membrane[16]

määramismeetod: IEA

integral component of presynaptic membrane[16]

määramismeetod: IEA

serotonergic synapse[16]

määramismeetod: IEA

Rakumembraan[38][17][16][42][43][44][37]

määramismeetod: IBA, IDA, IEA, TAS

integral component of plasma membrane[33][51]

määramismeetod: IC, IEA

integral component of plasma membrane[18]

määramismeetod: IEA

focal adhesion[19][16]

määramismeetod: IEA, ISS

sünaps[19][16]

määramismeetod: IEA, ISS

biological process

cellular response to organic substance[16]

määramismeetod: IEA

cellular response to retinoic acid[16]

määramismeetod: IEA

response to estradiol[16]

määramismeetod: IEA

cellular response to cGMP[16]

määramismeetod: IEA

response to hypoxia[16]

määramismeetod: IEA

negative regulation of neuron differentiation[16]

määramismeetod: IEA

ejaculation[16]

määramismeetod: IEA

response to nutrient[16]

määramismeetod: IEA

vasoconstriction[16]

määramismeetod: IEA

negative regulation of cerebellar granule cell precursor proliferation[16]

määramismeetod: IEA

Mälu[16]

määramismeetod: IEA

monoamine transport[20]

määramismeetod: IDA

response to organic substance[16]

määramismeetod: IEA

brain development[16]

määramismeetod: IEA

positive regulation of gene expression[16]

määramismeetod: IEA

positive regulation of cell cycle[16]

määramismeetod: IEA

serotonin transport[34][40]

määramismeetod: IDA, IEA

protein complex oligomerization[19][16]

määramismeetod: ISS, IEA

Tsirkadiaanrütm[16]

määramismeetod: IEA

transmembrane transport[52]

määramismeetod: IEA

social behavior[53][16]

määramismeetod: ISS, IEA

serotonin uptake[54][28][47][29][48][49][50]

määramismeetod: IDA, IEA, IMP

neurotransmitter transport[17][18]

määramismeetod: IEA

negative regulation of organ growth[53][16]

määramismeetod: ISS, IEA

protein homooligomerization[16]

määramismeetod: IEA

response to toxic substance[55]

määramismeetod: IDA

negative regulation of synaptic transmission, dopaminergic[16]

määramismeetod: IEA

brain morphogenesis[53][16]

määramismeetod: ISS, IEA

positive regulation of serotonin secretion[16]

määramismeetod: IEA

neurotransmitter biosynthetic process[38]

määramismeetod: TAS

dopamine uptake involved in synaptic transmission[30]

määramismeetod: IBA

regulation of thalamus size[56]

määramismeetod: IMP

serotonin uptake[57][16][39][42][43][44][37]

määramismeetod: IBA, IDA, IEA, IMP

serotonin transport[16]

määramismeetod: IEA

physically interacts with

Amitriptüliin[58]

kasutus: Ensüümiinhibiitor

amoxapine[59]

kasutus: Ensüümiinhibiitor

atomoxetine[60]

kasutus: Ensüümiinhibiitor

(RS)-citalopram[61][62]

kasutus: Ensüümiinhibiitor

clomipramine[63]

kasutus: Ensüümiinhibiitor

dapoxetine[64]

kasutus: Ensüümiinhibiitor

desipramine[65]

kasutus: Ensüümiinhibiitor

desvenlafaxine[66]

kasutus: Ensüümiinhibiitor

(S)-duloxetine[67]

kasutus: Ensüümiinhibiitor

Estsitalopraam[68]

kasutus: Ensüümiinhibiitor

Fluoksetiin[69]

kasutus: Ensüümiinhibiitor

fluvoxamine[70]

kasutus: Ensüümiinhibiitor

imipramiin[71]

kasutus: Ensüümiinhibiitor

levomilnacipran[72]

kasutus: Ensüümiinhibiitor

lofepramine[73]

kasutus: Ensüümiinhibiitor

nefazodone[74]

kasutus: Ensüümiinhibiitor

Nortriptüliin[75]

kasutus: Ensüümiinhibiitor

paroxetine[76]

kasutus: Ensüümiinhibiitor

phenelzine[77]

kasutus: Ensüümiinhibiitor

protriptyline[78]

kasutus: Ensüümiinhibiitor

sertraliin[79]

kasutus: Ensüümiinhibiitor

(RS)-sibutramine[80]

kasutus: Ensüümiinhibiitor

trimipramine[81]

kasutus: Ensüümiinhibiitor

venlafaxine[82]

kasutus: Ensüümiinhibiitor

vilazodone[83]

kasutus: Ensüümiinhibiitor

vortioxetine[84]

kasutus: Ensüümiinhibiitor

ziprasidone[85]

kasutus: Ensüümiinhibiitor

zotepine[86]

kasutus: Ensüümiinhibiitor

Gene Atlas image

facilitates flow of

Serotoniin

täpne vaste

http://purl.uniprot.org/uniprot/P31645[87]

koosseisu osa

Sodium:neurotransmitter symporter, serotonin, N-terminal[13]

Commonsi kategooria

Serotonin transporters

Viited

  1. ↑ NCBI Gene, 30. mai 2020, 6532
  2. ↑ Transporter Classification database, 13. märts 2020
  3. ↑ Transporter Classification database, 29. aprill 2020
  4. ↑ Ensembl Release 99, ENSP00000261707
  5. ↑ Ensembl Release 99, ENSP00000385822
  6. ↑ Ensembl Release 99, ENSP00000378298
  7. ↑ Ensembl Release 99, ENSP00000463172
  8. ↑ Ensembl Release 99, ENSP00000498537
  9. ↑ 9,0 9,1 9,2 9,3 UniProt, 13. november 2019, P31645
  10. ↑ Freebase Data Dumps, 28. oktoober 2013
  11. ↑ 11,0 11,1 11,2 11,3 11,4 11,5 P31645, 9. august 2016, UniProt, inglise keel
  12. ↑ OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ 13,0 13,1 13,2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P31645
  14. ↑ 2.A.22.1.1, 2. oktoober 2019, hierarchical database ID heuristic
  15. ↑ inferred from protein domain or family
  16. ↑ 16,00 16,01 16,02 16,03 16,04 16,05 16,06 16,07 16,08 16,09 16,10 16,11 16,12 16,13 16,14 16,15 16,16 16,17 16,18 16,19 16,20 16,21 16,22 16,23 16,24 16,25 16,26 16,27 16,28 16,29 16,30 16,31 16,32 16,33 16,34 16,35 16,36 16,37 16,38 16,39 16,40 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, Ensembl genome database project, GOA
  17. ↑ 17,0 17,1 17,2 17,3 17,4 17,5 17,6 17,7 17,8 IEA, 9. mai 2019, P31645, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  18. ↑ 18,0 18,1 18,2 18,3 18,4 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, InterPro, GOA
  19. ↑ 19,0 19,1 19,2 19,3 ISS, 9. mai 2019, P31645, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  20. ↑ 20,0 20,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, Mouse Genome Informatics, IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity, GOA
  21. ↑ IPI, 9. mai 2019, P31645, Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  22. ↑ IPI, 9. mai 2019, P31645, Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  23. ↑ IPI, 9. mai 2019, P31645, Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  24. ↑ IPI, 9. mai 2019, P31645, The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  25. ↑ 25,0 25,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16. juuli 2018, Reactome, GOA
  26. ↑ IMP, 16. juuli 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  27. ↑ 27,0 27,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16. juuli 2018, InterPro, GOA
  28. ↑ 28,0 28,1 28,2 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16. juuli 2018, Ensembl genome database project, GOA
  29. ↑ 29,0 29,1 IDA, 16. juuli 2018, P31645, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  30. ↑ 30,0 30,1 30,2 IBA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16. juuli 2018, GO Central, GOA
  31. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1. jaanuar 2018, Reactome, GOA
  32. ↑ IMP, 1. jaanuar 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  33. ↑ 33,0 33,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1. jaanuar 2018, InterPro, GOA
  34. ↑ 34,0 34,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1. jaanuar 2018, Ensembl genome database project, GOA
  35. ↑ IDA, 1. jaanuar 2018, P31645, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  36. ↑ IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1. jaanuar 2018, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  37. ↑ 37,0 37,1 37,2 37,3 37,4 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  38. ↑ 38,0 38,1 38,2 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, Reactome, GOA
  39. ↑ 39,0 39,1 IDA, 9. mai 2019, P31645, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  40. ↑ 40,0 40,1 IDA, 1. jaanuar 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  41. ↑ IC, 16. juuli 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  42. ↑ 42,0 42,1 42,2 IDA, 9. mai 2019, P31645, Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  43. ↑ 43,0 43,1 43,2 IDA, 9. mai 2019, P31645, Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  44. ↑ 44,0 44,1 44,2 IDA, 9. mai 2019, P31645, Plasma serotonin levels and the platelet serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  45. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 1. jaanuar 2018, Gene Ontology Consortium, GOA
  46. ↑ IEA, 16. juuli 2018, P31645, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  47. ↑ 47,0 47,1 IDA, 16. juuli 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  48. ↑ 48,0 48,1 IDA, 16. juuli 2018, P31645, Plasma serotonin levels and the platelet serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  49. ↑ 49,0 49,1 IDA, 16. juuli 2018, P31645, Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  50. ↑ 50,0 50,1 IDA, 16. juuli 2018, P31645, Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  51. ↑ IC, 1. jaanuar 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  52. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, Gene Ontology Consortium, GOA
  53. ↑ 53,0 53,1 53,2 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, British Heart Foundation, GOA
  54. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16. juuli 2018, Community Assessment of Community Annotation with Ontologies, Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization, GOA
  55. ↑ IDA, 9. mai 2019, P31645, Differential expression of intestinal membrane transporters in cholera patients, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  56. ↑ IMP, 9. mai 2019, P31645, Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  57. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9. mai 2019, Community Assessment of Community Annotation with Ontologies, Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization, GOA
  58. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 200, inglise keel
  59. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 201, inglise keel
  60. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7118, inglise keel
  61. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7547, inglise keel
  62. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4621, inglise keel
  63. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2398, inglise keel
  64. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7901, inglise keel
  65. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2399, inglise keel
  66. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7158, inglise keel
  67. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 202, inglise keel
  68. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7177, inglise keel
  69. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 203, inglise keel
  70. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7189, inglise keel
  71. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 357, inglise keel
  72. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7435, inglise keel
  73. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7551, inglise keel
  74. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7247, inglise keel
  75. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2404, inglise keel
  76. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4790, inglise keel
  77. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7266, inglise keel
  78. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7285, inglise keel
  79. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 4798, inglise keel
  80. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 2586, inglise keel
  81. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7317, inglise keel
  82. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7321, inglise keel
  83. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7427, inglise keel
  84. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7351, inglise keel
  85. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 59, inglise keel
  86. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 103, inglise keel
  87. ↑ Identifiers.org
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q410142"