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doxorubicin

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chemical compound

Välised allikad

MedlinePlus drug identifier
a682221
CAS Registry Number
23214-92-8[1][2]
MeSH descriptor ID
D004317

teema nimetus kujul: Doxorubicin

Encyclopædia Britannica Online ID
science/doxorubicin

teema nimetus kujul: doxorubicin

MeSH concept ID
M0006784
DeCS ID
24023
ChEMBL ID
CHEMBL53463[3]
Human Metabolome Database ID
HMDB0015132[4][5]
MeSH tree code
D02.455.426.559.847.562.050.200.175
D04.615.562.050.200.175
D09.408.051.059.200.175
ECHA Substance Infocard ID
100.041.344[6]
PDB structure ID
1D12[7]
1I1E[8]
4DX7[9]
1P20[10]
2DR6[11]
4ZVM[12]
151D[13]
1DA9[14]
5MRA
DrugCentral ID
960[15]
NALT ID
10464
Probes And Drugs ID
PD003620
LIPID MAPS ID
LMPK13050001
NDF-RT ID
N0000147829[1]
Freebase
/m/05y6n3[16]
Microsoft Academic ID
2780097476
2781303535
LCCN
sh85001015[17]

teema nimetus kujul: Doxorubicin

PubChem CID
31703[18][5]
UniChem compound ID
919477[15]
PDB ligand ID
DM2
KEGG ID
D03899[19]
OpenAlex ID
C2909829705[20]
C2781303535[20]
KBpedia ID
Doxorubicin[21]
InChIKey
AOJJSUZBOXZQNB-TZSSRYMLSA-N[18][22]
DrugBank ID
00997[5]
ChEBI ID
28748[3][23][24]

mapping relation type: täpne vaste

WikiProjectMed ID
Doxorubicin
UNII
80168379AG[1][5]
SureChEMBL ID
SCHEMBL3243[4][5]
National Library of Israel J9U ID
987007292944205171[25]
ATC code
L01DB01[26]
DSSTOX compound identifier
DTXCID301480
Guide to Pharmacology Ligand ID
7069[27]
electronic Essential Medicines List medicine ID
87
KNApSAcK ID
C00053046[4][5]
UMLS CUI
C0013089[1]
C0699076[28]
DSSTox substance ID
DTXSID8021480[29][5]
ChemSpider ID
29400[30]
EC number
245-495-6[1]
NSC number
759155
GND
4150505-0
InChI
InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1[18]
WordNet 3.1 Synset ID
03234852-n[31]
RxNorm ID
3639[1]
HSDB ID
3070[32]

üksikjuht nähtusest

type of chemical entity

mille alamklass

anthracycline polyketide

osa objektist

doxorubicin metabolic process[33]

subjektil on roll: participant

response to doxorubicin[33]

subjektil on roll: reactant

doxorubicin transport[33]

subjektil on roll: cargo

ABC-type doxorubicin transporter activity[33]

subjektil on roll: cargo

kasutus

ravim

keemiline struktuur

image of molecular model or crystal lattice model

kujutab: ball-and-stick model

mass/kaal

543,174 aatommassiühik[18]

stereoisomer of

epirubicin[34]
3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside[34]

chemical formula

C₂₇H₂₉NO₁₁[18]

canonical SMILES

CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O[18]

isomeric SMILES

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O[18]

active ingredient in

Adriamycin[35]

World Health Organisation international non-proprietary name

doxorubicin[19]

found in taxon

Streptomyces peucetius[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69]
Actinoallomurus[70]
Soolekepike[71]
Ixora coccinea[72]
Dracocephalum kotschyi[73]
Xylopia laevigata[74]
harilik peet[75]
Streptomyces venezuelae[76]
Penicillium variabile[77][78]
Annona muricata[79][80][81]
Xylopia aromatica[82]
Roosa kirmik[83]
Ophioparma ventosa[84]
Moorea producens[85]
Streptomyces atratus[86]
Annona senegalensis[87]
Pestalotiopsis palmarum[88]
Viola abyssinica[89]
Eurycoma longifolia[90][90]
Ochrolechia parella[91]
Trichodesmium thiebautii[92]
Oscillatoria thiebautii[92]
Zinnia grandiflora[93]
Macrohyporia cocos[94]
Wolfiporia cocos[94]
Ipomoea nil[95]
Aspergillus sclerotiorum[96]
Laurencia tristicha[97]
Annona cherimolia[98]
Annona cherimola[98]
Penicillium brocae[99]
Quambalaria cyanescens[100]
hiina sidrunväändik[101]
Cordyceps farinosa[102]
Hamigera fusca[103]
Fusarium oxysporum[104]
Trichoderma cornu-damae[105]
Talaromyces aculeatus[78]
Annona mucosa[106]
Fusarium solani[107]
Alstonia macrophylla[108]
Streptomyces violascens[109]
Streptomyces[110][111][112][113][114][115]
Teratosphaeria[116]
Hallitus[117]
Dothiora[118]
Actinoalloteichus[119]
Alternaria[120]
Verrucosispora[121]
Myrothecium[122]
Nocardiopsis[123]
Dendrodochium[124]
Chrysosporium[125]
Oscillatoria[126]
Okeania[126]

medical condition treated

rinnavähk[127]
munasarjavähk[127]
bladder cancer[127]
neuroblastoma, susceptibility to[128]
hepatoblastoma[128]
transitional cell carcinoma[128]
plasmablastic lymphoma[128]
mature T-cell and NK-cell lymphoma[128]
mantle cell lymphoma[128]
T-cell lymphoma[128]
precursor T-cell lymphoblastic leukemia[128]
chronic lymphocytic leukemia[128]
acute myeloid leukemia[128]
invasive ductal carcinoma[128]
precursor T-cell acute lymphoblastic leukemia[128]
non-Hodgkin lymphoma[128]
primary mediastinal B-cell lymphoma[128]
bone sarcoma[128]
post-transplant lymphoproliferative disorder[128]
lümfoom[128]
hematologic cancer[128]
B-cell lymphoma[128]
diffuse large B-cell lymphoma[128]
low-grade serous carcinoma

physically interacts with

DNA topoisomerase II alpha[129]

subjektil on roll: Ensüümiinhibiitor

DNA topoisomerase II alpha[130]

subjektil on roll: Inhibiitor

pregnancy category

Australian pregnancy category D
US pregnancy category D

subjektil on roll

DNA polymerase inhibitors[131]
topoisomerase inhibitor[131]
antineoplastic antibiotics[132]
topoisomerase II inhibitor[132]
essential medicine
anthracycline antibiotic[133]

stylized name

DOXOrubicin[134]

on omadusega: Tall Man lettering

väljaandja: FDA

teema nimetus kujul: Doxorubicin

Commonsi kategooria

Doxorubicin

Viited

  1. ↑ 1,0 1,1 1,2 1,3 1,4 1,5 Global Substance Registration System, 17. november 2016, inglise keel, doxorubicin, 80168379AG
  2. ↑ CAS Common Chemistry, 8. aprill 2021, AOJJSUZBOXZQNB-TZSSRYMLSA-N, https://commonchemistry.cas.org/detail?cas_rn=23214-92-8
  3. ↑ 3,0 3,1 ChEMBL, 17. november 2016, inglise keel, DOXORUBICIN, CHEMBL53463
  4. ↑ 4,0 4,1 4,2 inferred from InChIKey
  5. ↑ 5,0 5,1 5,2 5,3 5,4 5,5 5,6 AOJJSUZBOXZQNB-TZSSRYMLSA-N, InChIKey
  6. ↑ ECHA Substance Infocard database, 27. detsember 2018, 100.041.344, Doxorubicin, CAS no.: 23214-92-8
  7. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 1D12, 1D12
  8. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 1I1E, 1I1E
  9. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 4DX7, 4DX7
  10. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 1P20, 1P20
  11. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 2DR6, 2DR6
  12. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 4ZVM, 4ZVM
  13. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 151D, 151D
  14. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 1DA9, 1DA9
  15. ↑ 15,0 15,1 UniChem
  16. ↑ Freebase Data Dumps, 28. oktoober 2013
  17. ↑ Integrated Authority File
  18. ↑ 18,0 18,1 18,2 18,3 18,4 18,5 18,6 PubChem, 17. november 2016, inglise keel, 31703, doxorubicin
  19. ↑ 19,0 19,1 ChEBI, 19. oktoober 2016, inglise keel, doxorubicin, 28748
  20. ↑ 20,0 20,1 OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  21. ↑ KBpedia, 9. juuli 2020
  22. ↑ ChEBI release 2020-09-01
  23. ↑ ChEBI release 2019-10-02
  24. ↑ International Chemical Identifier, InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
  25. ↑ National Library of Israel Names and Subjects Authority File
  26. ↑ DrugBank, inglise keel, 17. november 2015, 00997, Doxorubicin
  27. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. november 2016, inglise keel, 7069, doxorubicin
  28. ↑ UMLS 2023, 25. mai 2023, inferred by common MeSH mappings on source and on Wikidata
  29. ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  30. ↑ ChemSpider, 17. november 2016, inglise keel, 29400, Doxorubicin
  31. ↑ GF WordNet
  32. ↑ Hazardous Substances Data Bank, 10. mai 2021, 28. oktoober 2019, DOXORUBICIN, 3070
  33. ↑ 33,0 33,1 33,2 33,3 Gene Ontology release 2019-11-16
  34. ↑ 34,0 34,1 inferred from InChI
  35. ↑ RxNorm, 42512, 14. veebruar 2018
  36. ↑ Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase
  37. ↑ Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius
  38. ↑ Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952.
  39. ↑ A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin
  40. ↑ Exploration of geosmin synthase from Streptomyces peucetius ATCC 27952 by deletion of doxorubicin biosynthetic gene cluster
  41. ↑ Enhancement of doxorubicin production by expression of structural sugar biosynthesis and glycosyltransferase genes in Streptomyces peucetius.
  42. ↑ Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement
  43. ↑ Isolation and genetic manipulation of the antibiotic down-regulatory gene, wblA ortholog for doxorubicin-producing Streptomyces strain improvement
  44. ↑ Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production.
  45. ↑ Enhancing macrolide production in Streptomyces by coexpressing three heterologous genes.
  46. ↑ Exploration of two epimerase homologs in Streptomyces peucetius ATCC 27952.
  47. ↑ The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificity
  48. ↑ Switching antibiotics production on and off in actinomycetes by an IclR family transcriptional regulator from Streptomyces peucetius ATCC 27952.
  49. ↑ One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars.
  50. ↑ Complete genome sequence of Streptomyces peucetius ATCC 27952, the producer of anticancer anthracyclines and diverse secondary metabolites
  51. ↑ Implication of orphan histidine kinase (OhkAsp) in biosynthesis of doxorubicin and daunorubicin in Streptomyces peucetius ATCC 27952
  52. ↑ Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24
  53. ↑ Expression and characterization of DrrA and DrrB proteins of Streptomyces peucetius in Escherichia coli: DrrA is an ATP binding protein
  54. ↑ Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis
  55. ↑ Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
  56. ↑ The Streptomyces peucetius dpsY anddnrX Genes Govern Early and Late Steps of Daunorubicin and Doxorubicin Biosynthesis
  57. ↑ Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesis
  58. ↑ Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene
  59. ↑ Glucose kinases from Streptomyces peucetius var. caesius.
  60. ↑ NdgR, an IclR-like regulator involved in amino-acid-dependent growth, quorum sensing, and antibiotic production in Streptomyces coelicolor
  61. ↑ Precursor for biosynthesis of sugar moiety of doxorubicin depends on rhamnose biosynthetic pathway in Streptomyces peucetius ATCC 27952.
  62. ↑ Identification of the duplicated genes for S-adenosyl-l-methionine synthetase (metK1-sp and metK2-sp) in Streptomyces peucetius var. caesius ATCC 27952.
  63. ↑ Improvement in doxorubicin productivity by overexpression of regulatory genes in Streptomyces peucetius
  64. ↑ Enhanced doxorubicin production by Streptomyces peucetius using a combination of classical strain mutation and medium optimization
  65. ↑ The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production
  66. ↑ Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces
  67. ↑ Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces
  68. ↑ Limitations in doxorubicin production from Streptomyces peucetius
  69. ↑ Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis
  70. ↑ Halogenated Spirotetronates from Actinoallomurus
  71. ↑ A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011.
  72. ↑ Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea
  73. ↑ Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent
  74. ↑ Cytotoxic Alkaloids from the Stem of Xylopia laevigata.
  75. ↑ Antioxidant and cell growth activities of beet root pomace extracts
  76. ↑ Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates
  77. ↑ Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor
  78. ↑ 78,0 78,1 Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile.
  79. ↑ Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata
  80. ↑ New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata
  81. ↑ Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata
  82. ↑ Bioactive annonaceous acetogenins from the bark of Xylopia aromatica
  83. ↑ Cytotoxic Xanthone Derivatives from the Mangrove-Derived Endophytic Fungus Peniophora incarnata Z4
  84. ↑ Minor Pyranonaphthoquinones from the Apothecia of the Lichen Ophioparma ventosa
  85. ↑ Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens
  86. ↑ Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 ΔilaR
  87. ↑ Bioactive ent-kaurene diterpenoids from Annona senegalensis
  88. ↑ Sinopestalotiollides A-D, cytotoxic diphenyl ether derivatives from plant endophytic fungus Pestalotiopsis palmarum
  89. ↑ Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands
  90. ↑ 90,0 90,1 Quassinoids from Eurycoma longifolia
  91. ↑ Metabolites from the LichenOchrolechia parellaGrowing under Two Different Heliotropic Conditions⊥
  92. ↑ 92,0 92,1 Isolation of Isotrichophycin C and Trichophycins G-I from a Collection of Trichodesmium thiebautii
  93. ↑ Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora
  94. ↑ 94,0 94,1 Cytotoxic Lanostanoids from Poria cocos
  95. ↑ Diterpene glycosides from the seeds of Pharbitis nil.
  96. ↑ Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178.
  97. ↑ Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan.
  98. ↑ 98,0 98,1 Annomolin and annocherimolin, new cytotoxic annonaceous acetogenins from Annona cherimolia seeds
  99. ↑ Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina
  100. ↑ Quambalarine B, a Secondary Metabolite from Quambalaria cyanescens with Potential Anticancer Properties.
  101. ↑ Identification of key structural characteristics of Schisandra chinensis lignans involved in P-glycoprotein inhibition.
  102. ↑ Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa
  103. ↑ Non-geminal Aliphatic Dihalogenation Pattern in Dichlorinated Diaporthins from Hamigera fusca NRRL 35721
  104. ↑ Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum
  105. ↑ Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae
  106. ↑ A novel constituent from Rollinia mucosa, rollicosin, and a new approach to develop annonaceous acetogenins as potential antitumor agents
  107. ↑ Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani
  108. ↑ Alstoniaphyllines A-C, unusual nitrogenous derivatives from the bark of Alstonia macrophylla
  109. ↑ Violapyrones A-G, α-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces
  110. ↑ Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp
  111. ↑ Cytotoxic Dibohemamines D-F from a Streptomyces Species.
  112. ↑ Polyketides and Anthranilic Acid Possessing 6-Deoxy-α-l-talopyranose from a Streptomyces Species.
  113. ↑ Komodoquinone A, a Novel Neuritogenic Anthracycline, from Marine Streptomyces sp. KS3
  114. ↑ Cytotoxic Bagremycins from Mangrove-Derived Streptomyces sp. Q22.
  115. ↑ Bioactive Streptoglutarimides A-J from the Marine-Derived Streptomyces sp. ZZ741
  116. ↑ Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa.
  117. ↑ Condensation of Macrocyclic Polyketides Produced by Penicillium sp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway
  118. ↑ Hormonemate Derivatives from Dothiora sp., an Endophytic Fungus.
  119. ↑ Bioactive Alkaloids from the Actinomycete Actinoalloteichus sp. ZZ1866
  120. ↑ Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus
  121. ↑ Cytotoxic Kendomycins Containing the Carbacylic Ansa Scaffold from the Marine-Derived Verrucosispora sp. SCSIO 07399
  122. ↑ Cytotoxic and Antibacterial Quinone Sesquiterpenes from a Myrothecium Fungus
  123. ↑ Cytotoxic p-Terphenyls from a Marine-Derived Nocardiopsis Species
  124. ↑ Polyhydroxy Cyclohexanols from a Dendrodochium sp. Fungus Associated with the Sea Cucumber Holothuria nobilis Selenka
  125. ↑ Chrysosporazines F-M: P-Glycoprotein Inhibitory Phenylpropanoid Piperazines from an Australian Marine Fish Derived Fungus, Chrysosporium sp. CMB-F294
  126. ↑ 126,0 126,1 Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium
  127. ↑ 127,0 127,1 127,2 N0000147829, 13. detsember 2016, NDF-RT, inglise keel
  128. ↑ 128,00 128,01 128,02 128,03 128,04 128,05 128,06 128,07 128,08 128,09 128,10 128,11 128,12 128,13 128,14 128,15 128,16 128,17 128,18 128,19 Drug Indications Extracted from FAERS, 2. oktoober 2018
  129. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 7069, inglise keel
  130. ↑ Open Targets Platform, 14. august 2023, https://platform.opentargets.org/drug/CHEMBL53463
  131. ↑ 131,0 131,1 N0000147829, 5. märts 2018, NDF-RT
  132. ↑ 132,0 132,1 Medical Subject Headings, 15. märts 2018, D004317
  133. ↑ N0000147829, 27. veebruar 2018, NDF-RT
  134. ↑ https://www.fda.gov/drugs/medication-errors-related-cder-regulated-drug-products/fda-name-differentiation-project, 2. september 2022
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q18936"