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vemurafenib

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keemiline ühend

Välised allikad

Freebase
/m/0hqvq1s[1]
Reaxys registry number
12833468[2]
PubChem CID
42611257[3][4]
MeSH descriptor ID
D000077484

teema nimetus kujul: Vemurafenib

UniChem compound ID
649459[5]
Quora topic ID
Vemurafenib[6]
LiverTox ID
Vemurafenib
PDB ligand ID
032
KEGG ID
D09996[2]
UNII
207SMY3FQT[7][4]
ATC code
L01XE15[8]
DeCS ID
57657
PDB structure ID
3OG7[9]
5HES[10]
4RZV[11]
OpenAlex ID
C2776131300[12]
ChEMBL ID
CHEMBL1229517[13]
DrugBank ID
DB08881[4]
BBC Things ID
513b52df-f7fb-4032-9537-4d0e25ce26f0[14]
InChIKey
GPXBXXGIAQBQNI-UHFFFAOYSA-N[3][15]
SPLASH
splash10-0006-0024900000-4911e6c7ad52fd2c2896
Human Metabolome Database ID
HMDB0259779[16][4]
CAS Registry Number
918504-65-1[2][17]
ChEBI ID
63637[2][18]

mapping relation type: täpne vaste

WikiProjectMed ID
Vemurafenib
InChI
InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)[3]
National Drug Code
50242-090
SureChEMBL ID
SCHEMBL298931[4]
MeSH tree code
D02.065.884.919
D02.886.590.700.919
D03.633.100.473.936
Microsoft Academic ID
2776131300
Guide to Pharmacology Ligand ID
5893[19]
HSDB ID
8143[20]
UMLS CUI
C3192263
DSSTOX compound identifier
DTXCID00161201
PatientsLikeMe treatment ID
vemurafenib
ECHA Substance Infocard ID
100.287.801
MedlinePlus drug identifier
a612009
ChemSpider ID
24747352[21]
EC number
850-250-7
NDF-RT ID
N0000183250[22]
DrugCentral ID
4185[5]
World Health Organisation international non-proprietary name numeric ID
9286
DSSTox substance ID
DTXSID50238710[23][4]
RxNorm ID
1147220
Probes And Drugs ID
PD003414

üksikjuht nähtusest

type of chemical entity

mille alamklass

keemiline ühend

kasutus

ravim

keemiline struktuur

mass/kaal

489,073 aatommassiühik[3]

chemical formula

C₂₃H₁₈ClF₂N₃O₃S[3]

canonical SMILES

CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F[3]

active ingredient in

Zelboraf[24]

World Health Organisation international non-proprietary name

vemurafenib[2]

medical condition treated

hairy cell leukemia[25]
metastatic melanoma[25]
nahavähk[25]
Erdheim-Chester disease[25]
melanoom[25]

significant drug interaction

efavirenz[26]

side effect: long QT syndrome

theophylline monohydrate[26]

side effect: Achor-Smith syndrom

fosphenytoin[26]

side effect: long QT syndrome

physically interacts with

B-Raf proto-oncogene, serine/threonine kinase[27]

subjektil on roll: Ensüümiinhibiitor

Raf-1 proto-oncogene, serine/threonine kinase[27]

subjektil on roll: Ensüümiinhibiitor

pregnancy category

Australian pregnancy category D
US pregnancy category D

LiverTox likelihood score

LiverTox toxicity likelihood category E*[28]

subjektil on roll

antineoplastic[29]
protein kinase inhibitors[30]
xenobiotic-transporting ATPase inhibitor[30]
Ensüümiinhibiitor[29]

Commonsi kategooria

Vemurafenib

Viited

  1. ↑ Freebase Data Dumps, 28. oktoober 2013
  2. ↑ 2,0 2,1 2,2 2,3 2,4 ChEBI, 18. oktoober 2016, inglise keel, vemurafenib, 63637
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 PubChem, 18. oktoober 2016, inglise keel, 42611257, Vemurafenib
  4. ↑ 4,0 4,1 4,2 4,3 4,4 4,5 GPXBXXGIAQBQNI-UHFFFAOYSA-N, InChIKey
  5. ↑ 5,0 5,1 UniChem
  6. ↑ Quora
  7. ↑ Global Substance Registration System, 18. oktoober 2016, inglise keel, vemurafenib, 207SMY3FQT
  8. ↑ DrugBank, inglise keel, 17. november 2015, 08881, Vemurafenib
  9. ↑ Protein Data Bank, 18. oktoober 2016, inglise keel, 3OG7, 3OG7
  10. ↑ Protein Data Bank, 18. oktoober 2016, inglise keel, 5HES, 5HES
  11. ↑ Protein Data Bank, 18. oktoober 2016, inglise keel, 4RZV, 4RZV
  12. ↑ OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ ChEMBL, 18. oktoober 2016, inglise keel, VEMURAFENIB, CHEMBL1229517
  14. ↑ BBC Things
  15. ↑ ChEBI release 2020-09-01
  16. ↑ inferred from InChIKey
  17. ↑ CAS Common Chemistry, 8. aprill 2021, GPXBXXGIAQBQNI-UHFFFAOYSA-N, https://commonchemistry.cas.org/detail?cas_rn=918504-65-1
  18. ↑ International Chemical Identifier, InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
  19. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 18. oktoober 2016, inglise keel, 5893, vemurafenib
  20. ↑ Hazardous Substances Data Bank, 10. mai 2021, 28. oktoober 2019, Vemurafenib, 8143
  21. ↑ ChemSpider, 18. oktoober 2016, inglise keel, 24747352, Vemurafenib
  22. ↑ NDF-RT, 19. jaanuar 2016, inglise keel, VEMURAFENIB, N0000183250
  23. ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  24. ↑ RxNorm, 1147224, 14. veebruar 2018
  25. ↑ 25,0 25,1 25,2 25,3 25,4 Drug Indications Extracted from FAERS, 2. oktoober 2018
  26. ↑ 26,0 26,1 26,2 A reference set of clinically relevant adverse drug-drug interactions, hypothetically
  27. ↑ 27,0 27,1 IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 5893, inglise keel
  28. ↑ LiverTox, 8. aprill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Vemurafenib, 28. juuni 2018
  29. ↑ 29,0 29,1 Medical Subject Headings, 15. märts 2018, C551177
  30. ↑ 30,0 30,1 N0000183250, 5. märts 2018, NDF-RT
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q423111"