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Interleukin 6

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mammalian protein found in Homo sapiens

Välised allikad

Freebase
/m/05gpxj[1]
RefSeq protein ID
NP_000591[2]
NP_001305024[2]
XP_005249802[2]
XP_011513692[2]
NP_001358025[2]
PDB structure ID
4O9H[3]
1ALU[3]
1IL6[3]
1P9M[3]
2IL6[3]
4CNI[3]
4J4L[3]
4NI7[3]
4NI9[3]
4ZS7[3]
Ensembl protein ID
ENSP00000385675[4]
ENSP00000258743[5]
ENSP00000384928[6]
ENSP00000385043[7]
ENSP00000385227[8]
ENSP00000385718[9]
ENSP00000405150[10]
Microsoft Academic ID
11988809
UniProt protein ID
P05231[11]
BNCF Thesaurus ID
73989
OpenAlex ID
C11988809[12]

üksikjuht nähtusest

valk[11]

osa objektist

interleukin-6[13]
four-helical cytokine-like, core[13]
Interleukin-6/GCSF/MGF, conserved site, protein family[14]

found in taxon

Homo sapiens[11]

encoded by

IL6[11]

molecular function

cytokine activity[15][16][17][18][19][20]

määramismeetod: NAS, IDA, ISS, IEA

growth factor activity[21][17][22][23]

määramismeetod: IDA, IEA, TAS

interleukin-6 receptor binding[24][25][26][18]

määramismeetod: NAS, IEA, TAS, IPI

ravimi seotus vereplasma valkudega[27][28][29][30][31]

määramismeetod: IPI

cell component

extracellular region[32][17][18]

määramismeetod: IEA, TAS

interleukin-6 receptor complex[22][33]

määramismeetod: IDA

extracellular space[17][34][35][20]

määramismeetod: IDA, IEA

endoplasmic reticulum lumen[32]

määramismeetod: TAS

biological process

regulation of angiogenesis[36]

määramismeetod: IC

positive regulation of translation[37]

määramismeetod: IDA

platelet activation[38]

määramismeetod: TAS

humoral immune response[39]

määramismeetod: IC

defense response to virus[20]

määramismeetod: IDA

response to peptidoglycan[40]

määramismeetod: NAS

neuron projection development[41]

määramismeetod: IMP

defense response to Gram-positive bacterium[42]

määramismeetod: TAS

negative regulation of fat cell differentiation[43]

määramismeetod: NAS

positive regulation of peptidyl-serine phosphorylation[44]

määramismeetod: IDA

positive regulation of leukocyte chemotaxis[42]

määramismeetod: TAS

positive regulation of T cell proliferation[45]

määramismeetod: IDA

positive regulation of interleukin-6 production[46]

määramismeetod: IDA

positive regulation of peptidyl-tyrosine phosphorylation[44]

määramismeetod: IDA

positive regulation of acute inflammatory response[47]

määramismeetod: IDA

inflammatory response[35]

määramismeetod: IDA

negative regulation of collagen biosynthetic process[48]

määramismeetod: IDA

positive regulation of MAPK cascade[44][48]

määramismeetod: IDA

hepatic immune response[49][47]

määramismeetod: IDA, TAS

monocyte chemotaxis[50]

määramismeetod: IC

positive regulation of DNA-binding transcription factor activity[51]

määramismeetod: IDA

negative regulation of apoptotic process[52]

määramismeetod: IDA

positive regulation of osteoblast differentiation[53]

määramismeetod: TAS

positive regulation of NF-kappaB transcription factor activity[48]

määramismeetod: IDA

acute-phase response[49][17]

määramismeetod: IEA, TAS

Immuunvastus[18]

määramismeetod: IEA

regulation of vascular endothelial growth factor production[54]

määramismeetod: IDA

positive regulation of chemokine production[40][46]

määramismeetod: NAS, IDA

negative regulation of lipid storage[43]

määramismeetod: NAS

neutrophil mediated immunity[42]

määramismeetod: TAS

positive regulation of smooth muscle cell proliferation[46]

määramismeetod: IDA

positive regulation of type B pancreatic cell apoptotic process[55]

määramismeetod: TAS

response to glucocorticoid[35]

määramismeetod: IDA

defense response to Gram-negative bacterium[42]

määramismeetod: TAS

positive regulation of cell population proliferation[56][22]

määramismeetod: IDA, IMP

positive regulation of apoptotic process[57]

määramismeetod: IDA

positive regulation of B cell activation[19]

määramismeetod: IDA

Translatsioonijärgne modifikatsioon[32]

määramismeetod: TAS

regulation of signaling receptor activity[58]

määramismeetod: IEA

positive regulation of tyrosine phosphorylation of STAT protein[23][59]

määramismeetod: IDA

neutrophil apoptotic process[52]

määramismeetod: IDA

negative regulation of cell population proliferation[60]

määramismeetod: TAS

positive regulation of gene expression[59]

määramismeetod: IDA

endocrine pancreas development[16]

määramismeetod: ISS

negative regulation of bone resorption[16]

määramismeetod: ISS

positive regulation of transcription, DNA-templated[61][62][51]

määramismeetod: IDA, IMP

positive regulation of transcription by RNA polymerase II[16][44][63][64]

määramismeetod: IDA, ISS

glucagon secretion[16]

määramismeetod: ISS

cellular response to hydrogen peroxide[65]

määramismeetod: IDA

cellular response to lipopolysaccharide[66]

määramismeetod: IMP

T-helper 17 cell lineage commitment[67]

määramismeetod: ISS

positive regulation of T-helper 2 cell cytokine production[16]

määramismeetod: ISS

negative regulation of interleukin-1-mediated signaling pathway[16]

määramismeetod: ISS

cytokine-mediated signaling pathway[32][22][23]

määramismeetod: IDA, TAS

interleukin-6-mediated signaling pathway[32][63][68]

määramismeetod: IDA, TAS

positive regulation of receptor signaling pathway via JAK-STAT[64][48][68][69]

määramismeetod: IC, IDA

täpne vaste

http://purl.uniprot.org/uniprot/P05231[70]

koosseisu osa

Interleukin-6/GCSF/MGF, conserved site[13]

Viited

  1. ↑ Freebase Data Dumps, 28. oktoober 2013
  2. ↑ 2,0 2,1 2,2 2,3 2,4 NCBI Gene, 30. mai 2020, 3569
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 P05231, 9. august 2016, UniProt, inglise keel
  4. ↑ Ensembl Release 99, ENSP00000385675
  5. ↑ Ensembl Release 99, ENSP00000258743
  6. ↑ Ensembl Release 99, ENSP00000384928
  7. ↑ Ensembl Release 99, ENSP00000385043
  8. ↑ Ensembl Release 99, ENSP00000385227
  9. ↑ Ensembl Release 99, ENSP00000385718
  10. ↑ Ensembl Release 99, ENSP00000405150
  11. ↑ 11,0 11,1 11,2 11,3 UniProt, 13. november 2019, P05231
  12. ↑ OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ 13,0 13,1 13,2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P05231
  14. ↑ inferred from protein domain or family
  15. ↑ NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA
  16. ↑ 16,0 16,1 16,2 16,3 16,4 16,5 16,6 ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, GOA
  17. ↑ 17,0 17,1 17,2 17,3 17,4 IEA, 27. märts 2018, P05231, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  18. ↑ 18,0 18,1 18,2 18,3 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, InterPro, GOA
  19. ↑ 19,0 19,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA
  20. ↑ 20,0 20,1 20,2 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA
  21. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Proteome Inc., Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6), GOA
  22. ↑ 22,0 22,1 22,2 22,3 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Molecular cloning and expression of an IL-6 signal transducer, gp130, GOA
  23. ↑ 23,0 23,1 23,2 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF, GOA
  24. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Proteome Inc., Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production, GOA
  25. ↑ NAS, 27. märts 2018, P05231, Marked cell-type-specific differences in glycosylation of human interleukin-6, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  26. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
  27. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, IntAct protein interaction database, Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network, GOA
  28. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, IntAct protein interaction database, Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling, GOA
  29. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, IntAct protein interaction database, A human protein-protein interaction network: a resource for annotating the proteome, GOA
  30. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, IntAct protein interaction database, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
  31. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, IntAct protein interaction database, Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex, GOA
  32. ↑ 32,0 32,1 32,2 32,3 32,4 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Reactome, GOA
  33. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
  34. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
  35. ↑ 35,0 35,1 35,2 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA
  36. ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA
  37. ↑ IDA, 27. märts 2018, P05231, BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  38. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism, GOA
  39. ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA
  40. ↑ 40,0 40,1 NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
  41. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, GOA
  42. ↑ 42,0 42,1 42,2 42,3 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
  43. ↑ 43,0 43,1 NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes, GOA
  44. ↑ 44,0 44,1 44,2 44,3 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Mouse Genome Informatics, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells, GOA
  45. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Synergistic activation of human T cells by interleukin 1 and interleukin 6, GOA
  46. ↑ 46,0 46,1 46,2 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA
  47. ↑ 47,0 47,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, GOA
  48. ↑ 48,0 48,1 48,2 48,3 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, GOA
  49. ↑ 49,0 49,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE), GOA
  50. ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA
  51. ↑ 51,0 51,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells, GOA
  52. ↑ 52,0 52,1 IDA, 27. märts 2018, P05231, Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  53. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells, GOA
  54. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA
  55. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA
  56. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA
  57. ↑ IDA, 27. märts 2018, P05231, Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  58. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Gene Ontology Consortium, GOA
  59. ↑ 59,0 59,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway, GOA
  60. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Proteome Inc., Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA
  61. ↑ IMP, 27. märts 2018, P05231, Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  62. ↑ IDA, 27. märts 2018, P05231, B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  63. ↑ 63,0 63,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, GOA
  64. ↑ 64,0 64,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA
  65. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins, GOA
  66. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, Mouse Genome Informatics, SASH1 is a scaffold molecule in endothelial TLR4 signaling, GOA
  67. ↑ ISS, 27. märts 2018, P05231, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  68. ↑ 68,0 68,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2, GOA
  69. ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27. märts 2018, British Heart Foundation, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA
  70. ↑ Identifiers.org
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q412889"