Mine sisu juurde

5-hydroxytryptamine receptor 1A

Lehekülje sisu ei toetata teistes keeltes.

mammalian protein found in Homo sapiens

Välised allikad

Freebase
Microsoft Academic ID
RefSeq protein ID
Transporter Classification Database ID
Guide to Pharmacology Target ID
OpenAlex ID
Ensembl protein ID
UniProt protein ID

üksikjuht nähtusest

osa objektist

5-Hydroxytryptamine 1A receptor[9]
GPCR, rhodopsin-like, 7TM, protein family[10]

found in taxon

Homo sapiens[8]

encoded by

HTR1A[8]

molecular function

G protein-coupled receptor activity[11][12]

määramismeetod: IEA

signal transducer activity[13]

määramismeetod: IEA

G protein-coupled serotonin receptor activity[14][15][12][16][17]

määramismeetod: IDA, IEA, IMP, TAS

ravimi seotus vereplasma valkudega[18][19]

määramismeetod: IPI

serotonin binding[20]

määramismeetod: IBA

neurotransmitter receptor activity[20]

määramismeetod: IBA

receptor-receptor interaction[21]

määramismeetod: IDA

G protein-coupled receptor activity[22][23][20]

määramismeetod: IBA, IEA

G protein-coupled serotonin receptor activity[24][25][23][26][27][20]

määramismeetod: IBA, IDA, IEA, IMP, TAS

cell component

integral component of membrane[22][23]

määramismeetod: IEA

membrane[22]

määramismeetod: IEA

Rakumembraan[28][22]

määramismeetod: TAS, IEA

integral component of plasma membrane[29][12][30]

määramismeetod: IDA, IEA, TAS

integral component of plasma membrane[31][23][32][20]

määramismeetod: IBA, IDA, IEA, TAS

Dendriit[20]

määramismeetod: IBA

biological process

G protein-coupled receptor signaling pathway[28][33][25][22][23]

määramismeetod: IEA, IMP, TAS

regulation of behavior[23]

määramismeetod: IEA

vasoconstriction[23]

määramismeetod: IEA

adenylate cyclase-inhibiting serotonin receptor signaling pathway[17]

määramismeetod: IDA

serotonin metabolic process[34][26]

määramismeetod: ISS, IEA

behavioral fear response[34][26]

määramismeetod: ISS, IEA

regulation of dopamine metabolic process[34][26]

määramismeetod: ISS, IEA

regulation of serotonin secretion[34][26]

määramismeetod: ISS, IEA

exploration behavior[34][26]

määramismeetod: ISS, IEA

serotonin receptor signaling pathway[34][26]

määramismeetod: ISS, IEA

positive regulation of cell population proliferation[33]

määramismeetod: TAS

regulation of hormone secretion[23]

määramismeetod: IEA

proliferatsioon[23]

määramismeetod: IEA

Signaaliülekanne[22]

määramismeetod: IEA

animal behaviour[22]

määramismeetod: IEA

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger[20]

määramismeetod: IBA

adenylate cyclase-inhibiting serotonin receptor signaling pathway[27][20]

määramismeetod: IBA, IDA

chemical synaptic transmission[20]

määramismeetod: IBA

physically interacts with

flibanserin[35]

kasutus: Agonist

frovatriptan[36]

kasutus: Agonist

LP-12[37]

kasutus: Agonist

LP-211[38]

kasutus: Agonist

LP-44[39]

kasutus: Agonist

1-naphthylpiperazine[40]

kasutus: Agonist

5-carboxamidotryptamine[41]

kasutus: Agonist

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin[43][44]

kasutus: Agonist

aripiprazole[45]

kasutus: Agonist

bmy-14802[46]

kasutus: Agonist

cabergoline[47]

kasutus: Agonist

clozapine[48]

kasutus: Agonist

CP 93129[49]

kasutus: Agonist

donitriptan[50]

kasutus: Agonist

eletriptan[51]

kasutus: Agonist

EMDT[52]

kasutus: Agonist

flesinoxan[53]

kasutus: Agonist

lisuride[54]

kasutus: Agonist

LY293284[56]

kasutus: Agonist

LY334370[57]

kasutus: Agonist

nafadotride[58]

kasutus: Agonist

naratriptan[59]

kasutus: Agonist

f-15599[60]

kasutus: Agonist

ocaperidone[61]

kasutus: Agonist

quetiapine[63]

kasutus: Agonist

quinpirole[64]

kasutus: Agonist

rizatriptan[65]

kasutus: Agonist

ru-24969[66]

kasutus: Agonist

S-14506[67]

kasutus: Agonist

S-14671[68]

kasutus: Agonist

spiroxatrine[69]

kasutus: Agonist

sumatriptan[70]

kasutus: Agonist

tandospirone[71]

kasutus: Agonist

U92016A[72]

kasutus: Agonist

xanomeline[73]

kasutus: Agonist

zalospirone[74]

kasutus: Agonist

zolmitriptan[75]

kasutus: Agonist

apomorphine[76]

kasutus: Agonist

BMY-7378[77]

kasutus: Agonist

brl-15572[78]

kasutus: Agonist

bromocriptine[79]

kasutus: Agonist

buspirone[80]

kasutus: Agonist

fluparoxan[81]

kasutus: Agonist

gr-127935[82]

kasutus: Agonist

ipsapirone[83]

kasutus: Agonist

pergolide[84]

kasutus: Agonist

piribedil[85]

kasutus: Agonist

roxindole[86]

kasutus: Agonist

S-15535[87][88]

kasutus: Agonist

sb-216641[89]

kasutus: Agonist

terguride[90]

kasutus: Agonist

vilazodone[91]

kasutus: Agonist

vortioxetine[92]

kasutus: Agonist

ziprasidone[93]

kasutus: Agonist

(+)-butaclamol[94]

kasutus: Antagonist

chlorpromazine[95]

kasutus: Antagonist

cyamemazine[96]

kasutus: Antagonist

fluspirilene[97]

kasutus: Antagonist

iloperidone[99]

kasutus: Antagonist

apiose[100]

kasutus: Antagonist

ketanserin[101]

kasutus: Antagonist

mesoridazine[102]

kasutus: Antagonist

metitepine[103]

kasutus: Antagonist

NAN 190[104]

kasutus: Antagonist

pimozide[105]

kasutus: Antagonist

pindolol[106]

kasutus: Antagonist

pipamperone[107]

kasutus: Antagonist

pizotyline[108]

kasutus: Antagonist

raclopride[109]

kasutus: Antagonist

repinotan[110]

kasutus: Antagonist

risperidone[111]

kasutus: Antagonist

ritanserin[112]

kasutus: Antagonist

robalzotan[113]

kasutus: Antagonist

sertindole[114]

kasutus: Antagonist

spiperone[115]

kasutus: Antagonist

thioridazine[116]

kasutus: Antagonist

tiospirone[117]

kasutus: Antagonist

WAY-100135[118]

kasutus: Antagonist

WAY-100635[119]

kasutus: Antagonist

yohimbine[120]

kasutus: Antagonist

zotepine[121]

kasutus: Antagonist

xaliproden[122]

objektil on roll: Agonist

zimeldine[123]

objektil on roll: Antagonist

aripiprazole lauroxil[124]

objektil on roll: Partial agonist

gepirone[125]

objektil on roll: Agonist

buspirone hydrochloride[126]

objektil on roll: Partial agonist

koosseisu osa

GPCR, rhodopsin-like, 7TM[9]

Commonsi kategooria

5-HT1A serotonin receptor

teema peakategooria

Category:5-HT1A serotonin receptor

Viited

  1. NCBI Gene, 30. mai 2020, 3350
  2. Transporter Classification database, 13. märts 2020
  3. Transporter Classification database, 29. aprill 2020
  4. https://www.wikidata.org/w/index.php?title=Wikidata:Property_proposal/Guide_to_Pharmacology_Target_ID&oldid=709819452
  5. OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  6. Ensembl Release 99, ENSP00000316244
  7. Ensembl Release 99, ENSP00000423433
  8. 8,0 8,1 8,2 8,3 UniProt, 13. november 2019, P08908
  9. 9,0 9,1 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P08908
  10. inferred from protein domain or family
  11. IEA, 16. juuli 2018, P08908, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, UniProt
  12. 12,0 12,1 12,2 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, 16. juuli 2018, InterPro, GOA
  13. IEA, 1. jaanuar 2018, P08908, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, UniProt
  14. TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, 16. juuli 2018, Proteome Inc., Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity, GOA
  15. IMP, 16. juuli 2018, P08908, Role of glycosphingolipids in the function of human serotonin₁A receptors, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, UniProt
  16. IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, 16. juuli 2018, Ensembl genome database project, GOA
  17. 17,0 17,1 IDA, 16. juuli 2018, P08908, Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, UniProt
  18. IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Parkinsons Disease Gene Ontology Initiative, Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2, GOA
  19. IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, IntAct protein interaction database, Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity, GOA
  20. 20,0 20,1 20,2 20,3 20,4 20,5 20,6 20,7 20,8 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  21. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Parkinsons Disease Gene Ontology Initiative, Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2, GOA
  22. 22,0 22,1 22,2 22,3 22,4 22,5 22,6 IEA, 8. aprill 2019, P08908, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, UniProt
  23. 23,0 23,1 23,2 23,3 23,4 23,5 23,6 23,7 23,8 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, InterPro, GOA
  24. TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Proteome Inc., Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity, GOA
  25. 25,0 25,1 IMP, 8. aprill 2019, P08908, Role of glycosphingolipids in the function of human serotonin₁A receptors, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, UniProt
  26. 26,0 26,1 26,2 26,3 26,4 26,5 26,6 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Ensembl genome database project, GOA
  27. 27,0 27,1 IDA, 8. aprill 2019, P08908, Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, UniProt
  28. 28,0 28,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Reactome, GOA
  29. TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, 16. juuli 2018, Proteome Inc., The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor, GOA
  30. IDA, 16. juuli 2018, P08908, Role of glycosphingolipids in the function of human serotonin₁A receptors, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P08908&geneProductId=UniProtKB:P08908, UniProt
  31. TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Proteome Inc., The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor, GOA
  32. IDA, 8. aprill 2019, P08908, Role of glycosphingolipids in the function of human serotonin₁A receptors, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, UniProt
  33. 33,0 33,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, 8. aprill 2019, Proteome Inc., Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis, GOA
  34. 34,0 34,1 34,2 34,3 34,4 34,5 ISS, 8. aprill 2019, P08908, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08908, UniProt
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