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keemiline ühend

Välised allikad

CAS Registry Number
107753-78-6[1][2]
Microsoft Academic ID
2780815506
PubChem CID
5717[3][4]
DSSTOX compound identifier
DTXCID303746
UniChem compound ID
504235[5]
LiverTox ID
Zafirlukast
PDB ligand ID
ZLK
KEGG ID
C07206[6]
D00411[6]
OpenAlex ID
C2780815506[7]
ChEMBL ID
CHEMBL603[8]
InChIKey
YEEZWCHGZNKEEK-UHFFFAOYSA-N[3][9]
DrugBank ID
DB00549[4]
DSSTox substance ID
DTXSID5023746[10][4]
ChEBI ID
10100[8][11]

mapping relation type: täpne vaste

WikiProjectMed ID
Zafirlukast
ATC code
R03DC01[12]
UMLS CUI
C0378466[1]
C0526503[13]
SureChEMBL ID
SCHEMBL4175[14][4]
Guide to Pharmacology Ligand ID
3322[15]
Reaxys registry number
3641829[6]
NDF-RT ID
N0000148457[1]
SPLASH
splash10-0a4r-0259300000-1440474b4cb47824c9f2
InChI
InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)[3]
ECHA Substance Infocard ID
100.189.989[16]
ChemSpider ID
5515[17]
EC number
663-705-8[16]
Human Metabolome Database ID
HMDB0014689[14][4]
DrugCentral ID
2855[5]
Freebase
/m/0416g8[18]
MeSH descriptor ID
C062735[19]
MedlinePlus drug identifier
a697007
RxNorm ID
114970[1]
Probes And Drugs ID
PD002945
UNII
XZ629S5L50[1][4]

üksikjuht nähtusest

type of chemical entity

mille alamklass

keemiline ühend

kasutus

ravim

keemiline struktuur

mass/kaal

575,209007 aatommassiühik[20]

chemical formula

C₃₁H₃₃N₃O₆S[3]

canonical SMILES

CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(C=C2)CC3=CN(C4=C3C=C(C=C4)NC(=O)OC5CCCC5)C)OC[3]

defined daily dose

40 milligram[21]

route of administration: oral administration

active ingredient in

Accolate[22]

World Health Organisation international non-proprietary name

zafirlukast[6]

medical condition treated

bronhiaalastma[23]
bronhiaalastma[24]

approved by: FDA

algusaeg: 25. september 1996

physically interacts with

Cysteinyl leukotriene receptor 1[25]

subjektil on roll: Antagonist

Cysteinyl leukotriene receptor 2[25]

subjektil on roll: Antagonist

pregnancy category

Australian pregnancy category B1
US pregnancy category B

LiverTox likelihood score

LiverTox toxicity likelihood category C[26]

subjektil on roll

anti-asthmatic agents[27]
leukotriene antagonists[27]

Commonsi kategooria

Zafirlukast

Viited

  1. ↑ 1,0 1,1 1,2 1,3 1,4 Global Substance Registration System, 19. november 2016, inglise keel, zafirlukast, XZ629S5L50
  2. ↑ CAS Common Chemistry, 9. aprill 2021, YEEZWCHGZNKEEK-UHFFFAOYSA-N, https://commonchemistry.cas.org/detail?cas_rn=107753-78-6
  3. ↑ 3,0 3,1 3,2 3,3 3,4 PubChem, 19. november 2016, inglise keel, 5717, zafirlukast
  4. ↑ 4,0 4,1 4,2 4,3 4,4 4,5 YEEZWCHGZNKEEK-UHFFFAOYSA-N, InChIKey
  5. ↑ 5,0 5,1 UniChem
  6. ↑ 6,0 6,1 6,2 6,3 ChEBI, 3. oktoober 2016, inglise keel, zafirlukast, 10100
  7. ↑ OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  8. ↑ 8,0 8,1 ChEMBL, 19. november 2016, inglise keel, ZAFIRLUKAST, CHEMBL603
  9. ↑ ChEBI release 2020-09-01
  10. ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  11. ↑ International Chemical Identifier, InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
  12. ↑ DrugBank, inglise keel, 17. november 2015, 00549, Zafirlukast
  13. ↑ UMLS 2023, 25. mai 2023, inferred by common MeSH mappings on source and on Wikidata
  14. ↑ 14,0 14,1 inferred from InChIKey
  15. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 19. november 2016, inglise keel, 3322, zafirlukast
  16. ↑ 16,0 16,1 ECHA Substance Infocard database, 27. detsember 2018, 100.189.989, cyclopentyl N-[3-({2-methoxy-4-[(2-methylbenzenesulfonyl)carbamoyl]phenyl}methyl)-1-methyl-1H-indol-5-yl]carbamate, CAS no.: 107753-78-6
  17. ↑ ChemSpider, 19. november 2016, inglise keel, 5515, Zafirlukast
  18. ↑ Freebase Data Dumps, 28. oktoober 2013
  19. ↑ Medical Subject Headings, 14. märts 2018, C062735
  20. ↑ PubChem, 3. oktoober 2016, inglise keel, 5717, zafirlukast
  21. ↑ https://www.whocc.no/atc_ddd_index/?code=R03DC01
  22. ↑ RxNorm, 135092, 14. veebruar 2018
  23. ↑ N0000148457, 13. detsember 2016, NDF-RT, inglise keel
  24. ↑ Inxight: Drugs Database, 2. november 2018, https://drugs.ncats.io/drug/XZ629S5L50, http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020547s027lbl.pdf
  25. ↑ 25,0 25,1 IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 3322, inglise keel
  26. ↑ LiverTox, 8. aprill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Zafirlukast, 4. juuni 2019
  27. ↑ 27,0 27,1 Medical Subject Headings, 15. märts 2018, C062735
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q928378"