Mine sisu juurde

tivozanib

Lehekülje sisu ei toetata teistes keeltes.
Loo artikkel

See on automaatne vaade, mis põhineb projekti Vikiandmed andmetel.
Artiklit veel pole, kuid saad aidata seda luua.

keemiline ühend

Välised allikad

MedlinePlus drug identifier
a621018
CAS Registry Number
475108-18-0[1][2]
Microsoft Academic ID
2778816644
PubChem CID
9911830[3][4]
DSSTOX compound identifier
DTXCID60205690
UniChem compound ID
997738[5]
PDB ligand ID
AV9
ChEMBL ID
CHEMBL1289494[6]
InChIKey
SPMVMDHWKHCIDT-UHFFFAOYSA-N[3][7]
Guide to Pharmacology Ligand ID
6058[8]
ChEBI ID
91327[9][10]

mapping relation type: täpne vaste

WikiProjectMed ID
Tivozanib
Freebase
/m/0cc8_6z
InChI
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)[3]
ATC code
L01XE34
PDB structure ID
4ASE[11]
ChemSpider ID
8087481[12]
DrugBank ID
11800[13][4]
DSSTox substance ID
DTXSID20963865[4]
DrugCentral ID
5258[5]
Human Metabolome Database ID
HMDB0304847[14][4]
RxNorm ID
2534233
Probes And Drugs ID
PD003428
UNII
172030934T[1][4]

üksikjuht nähtusest

type of chemical entity

mille alamklass

keemiline ühend

kasutus

ravim

keemiline struktuur

mass/kaal

454,104 aatommassiühik[3]

chemical formula

C₂₂H₁₉ClN₄O₅[3]

canonical SMILES

CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl[3]

isomeric SMILES

CC1=C/C(=N\C(=O)Nc2ccc(cc2Cl)Oc3ccnc4c3cc(c(c4)OC)OC)/NO1[15]

physically interacts with

Fms related receptor tyrosine kinase 1[16]

subjektil on roll: Ensüümiinhibiitor

Fms related receptor tyrosine kinase 4[16]

subjektil on roll: Ensüümiinhibiitor

Kinase insert domain receptor[16]

subjektil on roll: Ensüümiinhibiitor

Viited

  1. ↑ 1,0 1,1 Global Substance Registration System, 18. november 2016, inglise keel, tivozanib, 172030934T
  2. ↑ CAS Common Chemistry, 7. aprill 2021, https://commonchemistry.cas.org/detail?cas_rn=475108-18-0, SPMVMDHWKHCIDT-UHFFFAOYSA-N
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 PubChem, 18. november 2016, inglise keel, 9911830, Tivozanib
  4. ↑ 4,0 4,1 4,2 4,3 4,4 SPMVMDHWKHCIDT-UHFFFAOYSA-N, InChIKey
  5. ↑ 5,0 5,1 UniChem
  6. ↑ ChEMBL, 18. november 2016, inglise keel, TIVOZANIB, CHEMBL1289494
  7. ↑ ChEBI release 2020-09-01
  8. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 18. november 2016, inglise keel, 6058, tivozanib
  9. ↑ ChEBI, 19. oktoober 2016, inglise keel, 1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea, 91327
  10. ↑ International Chemical Identifier, InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
  11. ↑ Protein Data Bank, 19. oktoober 2016, inglise keel, 4ASE, 4ASE
  12. ↑ ChemSpider, 18. november 2016, inglise keel, 8087481, Tivozanib
  13. ↑ DrugBank, inglise keel, 3. juuli 2018, 11800, Tivozanib
  14. ↑ inferred from InChIKey
  15. ↑ RCSB protein data bank, 16. veebruar 2021, AV9, inglise keel
  16. ↑ 16,0 16,1 16,2 IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 6058, inglise keel
Pärit leheküljelt "https://et.wikipedia.org/wiki/Eri:AboutTopic/Q7810457"