Mine sisu juurde

donepezil

Lehekülje sisu ei toetata teistes keeltes.

keemiline ühend

Välised allikad

Freebase
Reaxys registry number
7081955[2]
PubChem CID
MeSH descriptor ID
D000077265

teema nimetus kujul: Donepezil

Encyclopædia Britannica Online ID
topic/Aricept

teema nimetus kujul: Aricept

KEGG ID
DeCS ID
OpenAlex ID
ChEMBL ID
UNII
InChIKey
Human Metabolome Database ID
ATC code
ChEBI ID
53289[6][11]

mapping relation type: täpne vaste

145499[11]

mapping relation type: täpne vaste

DSSTox substance ID
UMLS CUI
Guide to Pharmacology Ligand ID
DrugBank ID
Römpp online ID
SureChEMBL ID
CAS Registry Number
MeSH tree code
MedlinePlus drug identifier
EC number
601-651-9[17]
NDF-RT ID
DSSTOX compound identifier
Microsoft Academic ID
UniChem compound ID
ECHA Substance Infocard ID
ChemSpider ID
HSDB ID
DrugCentral ID
WikiProjectMed ID
InChI
RxNorm ID
Probes And Drugs ID

üksikjuht nähtusest

type of chemical entity

mille alamklass

donepezil c-11[21]

kasutus

keemiline struktuur

mass/kaal

379,214744 aatommassiühik[22]

chemical formula

C₂₄H₂₉NO₃[3]

canonical SMILES

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC[3]

defined daily dose

7,5 milligram[23]

route of administration: oral administration

active ingredient in

Aricept[24]

World Health Organisation international non-proprietary name

donepezil[2]

medical condition treated

early-onset Alzheimer's disease[25]
vascular dementia[26]

significant drug interaction

Metadoon[27]

side effect: sinus bradycardia

Amiodaroon[28]

side effect: sinus bradycardia

sotalol[28]

side effect: sinus bradycardia

fingolimod[27]

side effect: sinus bradycardia

Krisotiniib[27]

side effect: sinus bradycardia

pasireotide[27]

side effect: sinus bradycardia

ivabradine[27]

side effect: sinus bradycardia

neostigmine[28]

side effect: sinus bradycardia

rivastigmine[28]

side effect: sinus bradycardia

galantamine[28]

side effect: sinus bradycardia

Amiodaroon[28]

side effect: torsades de pointes

Amiodaroon[28]

side effect: long QT syndrome

sotalol[28]

side effect: torsades de pointes

Metadoon[27]

side effect: torsades de pointes

Metadoon[27]

side effect: long QT syndrome

fingolimod[27]

side effect: torsades de pointes

fingolimod[27]

side effect: long QT syndrome

Krisotiniib[27]

side effect: torsades de pointes

Krisotiniib[27]

side effect: long QT syndrome

pasireotide[27]

side effect: torsades de pointes

pasireotide[27]

side effect: long QT syndrome

ivabradine[27]

side effect: torsades de pointes

ivabradine[27]

side effect: long QT syndrome

succinylcholine[28]

physically interacts with

Acetylcholinesterase[29]

subjektil on roll: Ensüümiinhibiitor

subjektil on roll

acetylcholinesterase inhibitor[30][31]
nootropic[31]

Commonsi kategooria

Donepezil

Viited

  1. Freebase Data Dumps, 28. oktoober 2013
  2. 2,0 2,1 2,2 ChEBI, 3. oktoober 2016, inglise keel, donepezil, 53289
  3. 3,0 3,1 3,2 3,3 3,4 PubChem, 19. november 2016, inglise keel, 3152, donepezil
  4. 4,0 4,1 4,2 4,3 4,4 4,5 4,6 ADEBPBSSDYVVLD-UHFFFAOYSA-N, InChIKey
  5. OpenAlex, 26. jaanuar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  6. 6,0 6,1 ChEMBL, 19. november 2016, inglise keel, DONEPEZIL, CHEMBL502
  7. 7,0 7,1 7,2 7,3 7,4 Global Substance Registration System, 19. november 2016, inglise keel, donepezil, 8SSC91326P
  8. ChEBI release 2020-09-01
  9. 9,0 9,1 9,2 inferred from InChIKey
  10. DrugBank, inglise keel, 17. november 2015, 00843, Donepezil
  11. 11,0 11,1 International Chemical Identifier, InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
  12. Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  13. UMLS 2023, 25. mai 2023, inferred by common MeSH mappings on source and on Wikidata
  14. IUPHAR/BPS Guide to PHARMACOLOGY, 19. november 2016, inglise keel, 6599, donepezil
  15. DrugBank, 19. november 2016, inglise keel, 00843, Donepezil
  16. CAS Common Chemistry, 9. aprill 2021, ADEBPBSSDYVVLD-UHFFFAOYSA-N, https://commonchemistry.cas.org/detail?cas_rn=120014-06-4
  17. 17,0 17,1 ECHA Substance Infocard database, 27. detsember 2018, 100.125.198, 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, CAS no.: 120014-06-4
  18. 18,0 18,1 UniChem
  19. ChemSpider, 19. november 2016, inglise keel, 3040, donepezil
  20. Hazardous Substances Data Bank, 10. mai 2021, 28. oktoober 2019, Donepezil, 7743
  21. inferred from SMILES
  22. PubChem, 3. oktoober 2016, inglise keel, 3152, donepezil
  23. https://www.whocc.no/atc_ddd_index/?code=N06DA02
  24. RxNorm, 135446, 14. veebruar 2018
  25. 25,0 25,1 N0000022050, 13. detsember 2016, NDF-RT, inglise keel
  26. 26,0 26,1 26,2 26,3 26,4 Drug Indications Extracted from FAERS, 2. oktoober 2018
  27. 27,00 27,01 27,02 27,03 27,04 27,05 27,06 27,07 27,08 27,09 27,10 27,11 27,12 27,13 27,14 A reference set of clinically relevant adverse drug-drug interactions, probably
  28. 28,0 28,1 28,2 28,3 28,4 28,5 28,6 28,7 28,8 A reference set of clinically relevant adverse drug-drug interactions, hypothetically
  29. IUPHAR/BPS Guide to PHARMACOLOGY, 17. august 2016, 6599, inglise keel
  30. N0000022050, 5. märts 2018, NDF-RT
  31. 31,0 31,1 Medical Subject Headings, 15. märts 2018, C076946