ivosidenib
Ilme
chemical compound
üksikjuht nähtusest
type of chemical entity
mille alamklass
kasutus
mass/kaal
582,139400904 aatommassiühik[11]
chemical formula
C₂₈H₂₂ClF₃N₆O₃[3]
canonical SMILES
C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N[3]
isomeric SMILES
C1CC(=O)N([C@@H]1C(=O)N(C2=CC(=CN=C2)F)[C@@H](C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N[3]
legal status (medicine)
boxed warning[12]
LiverTox likelihood score
LiverTox toxicity likelihood category E*[13]
Viited
- ↑ ChEBI release 2021-03-01
- ↑ International Chemical Identifier, InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1
- ↑ 3,0 3,1 3,2 3,3 3,4 3,5 PubChem, 20. november 2016, inglise keel, 71657455, Ivosidenib
- ↑ 4,0 4,1 4,2 4,3 4,4 WIJZXSAJMHAVGX-DHLKQENFSA-N, InChIKey
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 20. november 2016, inglise keel, 9217, ivosidenib
- ↑ 6,0 6,1 Global Substance Registration System, 20. november 2016, inglise keel, ivosidenib, Q2PCN8MAM6
- ↑ CAS Common Chemistry, 10. aprill 2021, WIJZXSAJMHAVGX-DHLKQENFSA-N, https://commonchemistry.cas.org/detail?cas_rn=1448347-49-6
- ↑ ChemSpider, 20. november 2016, inglise keel, 38772333, ivosidenib
- ↑ 9,0 9,1 UniChem
- ↑ inferred from InChIKey
- ↑ inferred from isomeric SMILES
- ↑ FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links., https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
- ↑ LiverTox, 8. aprill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Ivosidenib, 20. oktoober 2018